In Vitro Release of Metformin HCl from Polyvinyl Alcohol (PVA) - Gelatin Hydrogels Prepared by Gamma Irradiation
The aim of this present work is to use polyvinyl alcohol (PVA) – gelatin-based hydrogel prepared by γ-rays irradiation with different gelatin concentrations ranging from 0.5 - 2 %w/v for immobilization of Metformin HCl (MH) at dose range of 0 - 30 mg. The mixture were freezed-thawed for 3 cycles, irradiated using γ-rays with sterilization dose at 25 kGy (dose rates 5 kGy/h). Gel fraction and water absorption were determined gravimetrically. The surface morphology of hydrogels were observed using Scanning Electron Microscope (SEM). In vitro release of MH were taken using UV-Vis spectrophotometer. After evaluated, it was found that with increasing gelatin concentrations, gel fraction increases and water absorption decreases. With increasing gelatin concentration and drug dosage, the cumulative drug released decreases. From SEM observation, the hydrogel had a heterogeneous porous. The hydrogel based on PVA-gelatin can be considered as a matrix for controlled drug release and safe for humans since both PVA and gelatin are non-toxic.
K. J. Wadher, R. B. Kakde and M. J. Umekar, Int. J. Pharm. Investig. 1 (2011) 157.
J. Sauri, M Zachariah, R. Macovez et al., J. Drug Delivery Sci. Technol. 42 (2017) 215.
J. L. J. Blanco, J. M. Benito, C. O. Mellet et al., J. Drug Delivery Sci. Technol. 42 (2017) 18.
D. W. Kurniawan, D. A. Triyanto and V. V. F. R. Utami, Kartika: Jurnal Ilmiah Farmasi 6 (2018) 11. (in Indonesian)
K. V. R. N. S. Ramesh, S. Mohanalayam, O. Sarheed et al., Asian J. Pharm. 11 (2017) 118.
M. T. R. Chikukwa, M. Wesoly, A. B. Korzeniowska et al., Pharm. Dev. Technol. 25 (2020) 281.
X. Bai, M. Gao, S. Syed et al., Bioact. Mater. 3 (2018) 401.
Y. C. Qian, P. C. Chen, G. J. He et al., Molecules 19 (2014) 9850.
Erizal, E. W. Pratiwi, D. P. Perkasa et al., Jurnal Kimia Kemasan 40 (2018) 47. (in Indonesian)
Z. Velkova, G. Kirova, M. Stoytcheva et al., Eng. Life Sci. 18 (2018) 871.
D. Singh, A. Singh and R. Singh, J. Biomater. Sci., Polym. Ed. 26 (2015) 1269.
C. Vasile, D. Pamfil, E. Stoleru et al., Molecules 25 (2020) 1539.
A. Chyzy, M. Tomczykowa and M. E. Plonska-Brzezinska, Materials 13 (2020) 188.
S. Amin, S. Rajabnezhad and K. Kohli, Sci. Res. Essay 3 (2009) 1175.
H. Hariyanti, Erizal, M. Y. Yunus et al., Jurnal Sains Materi Indonesia 21 (2020) 143. (in Indonesian)
S. Mitura, A. Sionkowska and A. Jaiswal, J. Mater. Sci. - Mater. Med. 31 (2020) 50.
R. Song, M. W. Murphy, C. Li et al., Drug Des. Dev. Ther. 12 (2018) 3117.
Q. Xing, K. Yates, C. Vogt et al., Sci. Rep. 4 (2014) 4706.
G. Thakur, F. C. Rodrigues and K. Singh, Crosslinking Biopolymers for Advanced Drug Delivery and Tissue Engineering Applications, in: Cutting-Edge Enabling Technologies for Regenerative Medicine, Advances in Experimental Medicine and Biology 1078, Springer, Singapore (2018) 213.
P. N. Charron, T. A. Braddish and R. A. Oldinski, J. Mech. Behav. Biomed. Mater. 92 (2019) 90.
K. R. Park and Y. C. Nho, J. Appl. Polym. Sci. 91 ( 2004) 1612.
Erizal, D. Pribadi, E. Yulianti et al., Jurnal Sains Materi Indonesia 19 (2018) 139. (in Indonesian)
M. Kobayashi and H. S. Hyu, Materials. 3 (2010) 2753.
J. Tavakoli, A. J. Gascooke and Y. Tang, Top. Curr. Chem. 379 (2021) 1390.
Erizal and Z. Abidin, Jurnal Ilmiah Aplikasi Isotop dan Radiasi 7 (2011) 21. (in Indonesian)
K. Swaroop, M. J. Gaana, S. S. Shruthi et al., Studies on Swelling Behaviour of Radiolytically Synthesised PVA/Gelatin Hydrogels, AIP Conference Proceedings 2115, 030050 (2019).
K. Swaroop, L. P. Shrikant and H. M. Somashekarappa, Curr. Perspect. Chem. Sci. 9 (2021) 125.
K. Pal, A. K. Banthia and D. K. Majumdar, AAPS PharmSciTech 8 (2007) E1.
L. Arens, D. Barther, J. Landsgesell et al., Soft Matter 15 (2019) 9949.
Z. Xiang, P. Sarazin and B. D. Favis, Biomacromolecules 10 (2009) 2053.
M. Miotke, J. Strankowska, J. Kwela et al., Polym. Bull. 77 (2019) 483.
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